9 edition of Telomeres and telomerase in aging, disease, and cancer found in the catalog.
Includes bibliographical references and index.
|Statement||K. Lenhard Rudolph, editor.|
|Contributions||Rudolph, K. Lenhard|
|LC Classifications||QP86 .T34 2008|
|The Physical Object|
|Pagination||xiv, 311 p. :|
|Number of Pages||311|
|LC Control Number||2007931191|
For years, researchers have tried to find a simple and safe way to manipulate telomerase, preserve telomeres, and create cures for telomere diseases. "Once human telomerase . Buy Telomeres and Telomerase in Ageing, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing Softcover reprint of hardcover 1st ed. by Various,., Rudolph, K. Lenhard (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible Various.
Telomeres' Relation to Aging and Cancer. This is what happens with cancer and why these "immortal" cells can cause disease and death. It is believed that cancer occurs because a genetic mutation can trigger the production of an enzyme, known as telomerase, which prevents telomeres . 2. Telomeres and telomerase. Progressive telomere shortening from cell division (replicative aging) provides a barrier for tumor progression. However, one of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of rase is a cellular reverse transcriptase (molecular motor) that adds new DNA .
Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4, references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art. A new book by Nobel Prize laureate Elizabeth Blackburn, Ph.D., The Telomere Effect, suggests that the science indicates that this may be the case. For years, a huge goal within the scientific community has been to safely slow down aging and avoid chronic diseases. Theories of aging have abounded.
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Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing.
This book summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. Twenty-five years after the disclosure of the telomeric DNA sequence and 22 years after the discovery of telomerase, it has become clear that telomeres and telomerase influence disease of human ageing including cancer.
This book summarizes our current knowledge on the role of telomeres and telomerase in ageing, regeneration, and cancer with a special focus on ageing stem cells.
Telomere Lengthening: Curing All Disease Including Aging and Cancer Paperback – January 1, by Ph.D. Bill Andrews (Author), Jon Cornell (Author) out of 5 stars 2 ratings5/5(2). Telomeres and Telomerase in Aging, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing K.
Lenhard Rudolph, K. Lenhard Rudolph The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and health span in the growing populations of the elderly.
This book summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. In addition, the book describes our current knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction.
Nat Rev Genet. Aug;6(8) Telomeres and human disease: ageing, cancer and beyond. Blasco MA(1). Author information: (1)Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre (CNIO), Madrid, Spain.
[email protected] Telomere length and telomerase activity are important factors in the pathobiology of human disease.
Capping decades of research, a new study may offer a breakthrough in treating dyskeratosis congenita and other so-called telomere diseases, in which cells age prematurely. Using cells donated by patients with the disease, researchers at the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center identified several small molecules that appear to reverse this cellular aging.
Dear Colleagues, Telomeres and telomerase have been receiving ever-increasing interest from the scientific community. This includes biologists deciphering the complex mechanisms and interactions between the different components of telomeres and telomerase, as well as clinicians aiming to use telomere lengths as a biomarker for aging and diseases.
Telomere and Telomerase Dynamics. Telomeres are specialized functional complexes (parts of DNA molecules) that are cited at the end of DNA; they protect the ends of eukaryotic chromosomes from terminal attrition (Blackburn, ).On the other hand, telomerase is an enzyme responsible for synthesizes DNA at the chromosome terminal, lengthening the terminal regions of.
Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes. Telomere attrition can lead to potentially maladaptive cellular changes, block cell division, and interfere with tissue replenishment.
Recent advances in the understanding of human disease processes have clarified the roles of telomere biology, especially in diseases of human aging and in some aging-related. Twenty-five years after the disclosure of the telomeric DNA sequence and 22 years after the discovery of telomerase, it has become clear that telomeres and telomerase influence disease of human ageing including cancer.
This book summarizes our current knowledge on the role of telomeres and. Telomere length and telomerase activity are important factors in the pathobiology of human disease. Age-related diseases and premature ageing syndromes are characterized by short telomeres, which Cited by: Telomeres and telomerase provide a unique and important avenue of study in improving both life expectancy and quality of life due to their close association with aging and disease.
While major advances in our understanding of these two biological mediators have characterized the last two decades, previous studies have been limited by the inability to affect change in real time within living. The accumulation of short telomeres and of damage at telomeres over time in zebrafish anticipates the onset of tissue-specific phenotypes of aging, such as intestinal inflammation, and of aging-associated diseases, such as cachexia and, surprisingly, cancer (contrary to several oncogene-driven telomerase-knockout models) (Carneiro et al., ).
Telomeres are small structures that protect the ends of your chromosomes. Over time, they tend to get shorter. We’ll dive into the recent research surrounding telomere shortening, cancer, and aging.
It can escape this fate by becoming a cancer cell and activating an enzyme called telomerase, which prevents the telomeres from getting even shorter. Studies have found shortened telomeres in many cancers, including pancreatic, bone, prostate, bladder, lung, kidney, and head and neck.
In it, the co-authors make the case that while telomeres are just one pathway of aging, certain lifestyle changes might stabilize telomeres or increase telomerase and help prevent aging. The book. The Telomeres and Telomerase Group at the Spanish National Cancer Research Centre (CNIO) had previously developed an effective therapy for.
The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life.
Have you wondered why some sixty-year-olds look and feel like for/5(). Telomeres and telomerase provide a unique and important avenue of study in improving both life expectancy and quality of life due to their close association with aging and disease.
While major advances in our understanding of these two biological mediators have characterized the. A new study — using the Martins’ own cells — could be a breakthrough in treating DC and other so-called telomere diseases, in which cells age prematurely. The study identified several small molecules that appear to reverse this cellular aging process.
Study leader Suneet Agarwal, MD, PhD, a researcher in the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, hopes at.Telomerase deficiencies and cancer appear to lie at opposite ends of a spectrum similar to p loss of p53 is observed in most tumors and is tumor promoting in mouse models, whereas mice with enhanced p53 responses exhibit increased cancer resistance, a shortened life span, and a number of early aging-associated phenotypes (65, ).
In both. This video is a book review of Telomere Lengthening: Curing all diseases including cancer & aging by Dr. Bill Andrews and Jon Cornell produces 16% of the amount of telomerase to stop telomere.